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Esteróide Errado Encontrado No Epistane


krebz

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Acabei de achar um artigo interessante, segundo ele pesquisadores de doping do Mitsubishi Chemical Medience Corporation acharam ao menos um esteróide diferente do que é citado no suplemento.

Resumindo: O Epistane supostamente contem o esteroide designer (designer steroid, não sei como o pessoal chama em português esse tipo de esteroide) 17alpha-methyl 2alpha,3alpha-epithio 5alpha-androstane-17-beta-ol (que é chamado também por methylepithiostanol), mas não é encontrado no Epistane (ao menos segundo a pesquisa, no lote 105284 que foi usado) não foi encontrado. No lugar foi encontrado 17alpha-methyl 2beta,3beta-epithio 5alpha-androstane 17beta-ol (a diferença entre ela e a original é apenas a posição de um atomo) mas essa mudança de esteróide é comparada com o que o original deveria fazer (os graficos ali em baixo no artigo), e conclui que ele é mais fraco comparando com o que deveria ter.

MAS foi encontrado o 17alpha-methyl 5alpha-androst-2-en-17beta-ol, também conhecido como madol, DMT, desoxymethyl testosterone ou PheraPlex, que é tão bom quando o methylepithiostanol (terceira imagem do artigo).

Segundo ainda os pesquisadores, eles acham que o madol é liberado quando o methylepithiostanol é produzido.

Citação do artigo:

There’s something not quite right about IBE’s designer supplement Epistane. According to an article by Japanese doping hunters working for Mitsubishi Chemical Medience Corporation, published in Drug Testing & Analysis, at least one batch of the preparation contains a different steroid from the one listed on the label.

Epistane is supposed to contain the designer steroid 17alpha-methyl 2alpha,3alpha-epithio 5alpha-androstane-17-beta-ol. This steroid goes by the names of 17alpha-methylepithiostanol or methylepithiostanol. In 2007 methylepithiostanol appeared on the grey market.

When we looked it up in Julius Vida’s steroids bible Androgens and Anabolic Agents (1969) we found impressive data based on animal studies, which you can see below. The upper steroid is methylepithiostanol, which is what Epistane is supposed to contain.

VP = effect on the prostate; SV = effect on the sperm vesicles; LA = effect on the sphincter muscle. VP and SV are markers for masculinising side effects; LA is a marker for the desired muscle building effect. The values are compared with methyl testosterone, which was adjusted to 100.

epistaneanalysis3.gif

epistaneanalysis.gif

epistaneanalysis2.gif

As you can see, methylepithiostanol is a fantastic oral steroid with few side effects and a huge anabolic effect. So it’s a shame that it’s not in Epistane. At least, it’s not in Lot 105284 of IBE’s Epistane. Instead, the researchers found 17alpha-methyl 2beta,3beta-epithio 5alpha-androstane 17beta-ol in the capsules. The difference is in the spatial position of the sulphur atom: In the steroid that the researchers found the sulphur atom hangs at the bottom of the steroid skeleton. But Epistane should contain a compound in which the sulphur atom is at the top of the steroid skeleton.

The performance of the steroid in Epistane is shown in the second row of the table above, and it’s not very impressive.

The researchers are not 100% sure of their case. They used NMR to find out whether they were dealing with 17alpha-methyl 2alpha,3alpha-epithio 5alpha-androstane-17beta-ol, or with 17alpha-methyl 2beta,3beta-epithio 5alpha-androstane-17beta-ol. The Japanese used data from a 1975 study to interpret the results of their own measurements. But if the older study is not correct, the Japanese study isn’t either.

What’s more, the researchers found another substance in the capsules as well: the designer steroid 17alpha-methyl 5alpha-androst-2-en-17beta-ol. You may know this steroid under another name: madol, DMT, desoxymethyl testosterone or PheraPlex. This steroid’s performance is shown at the bottom of the table above. It’s just as good as methylepithiostanol.

The researchers think that madol is released when methylepithiostanol is manufactured. In the human body methylepithiostanol is converted into madol. The researchers gave human subjects IBE's Epistane, and found no traces of methylepithiostanol in their urine – but they did find madol. [This conversion apparently did not go so well in the rodents that Vida used – Ed.] So the contamination isn’t that bad.

epistaneanalysis4.gif

According to the values from the table in Vida, it seems that madol may be even stronger than methylepithiostanol. So even if they take the wrong Epistane, users still stand to grow.

A modest discussion on the Japanese publication has arisen on bodybuilding.com. See here.

Whether the other Epistane products on the market, like Havoc, Epithin-E, Methyl-E, Hemaguno, Oxydrol, Kryptonite, Epidrol, Hemobolin, Epi-Max, Epiotren, CynergE, E-Stane, SuprEmacy, Jacked and Spawn, also contain the wrong methylepithiostanol it’s not possible to say on the basis of this research.

Fonte do artigo: http://www.ergo-log.com/epistane.html

Fonte da pesquisa: http://www3.interscience.wiley.com/journal/123208964/abstract?CRETRY=1&SRETRY=0

Eu sei que isso não muda a vida de ninguem, quem sabe foi apenas o lote que estava errado (e os ganhos continuariam os mesmos por ter o madol).

Apenas estou postando o artigo para quem se interessa por pesquisas ;)

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