alguem tem algum estudo se atendo apenas à toxicidade da vitamina d?
"The weight of published evidence on toxicity shows that the lowest dose of vitamin D causing hypercalcemia in some healthy adults is 1000 μg (40,000 IU)/d of the vitamin D2 form. This translates to 1000 μg, or 1 mg, taken daily for many months. Few studies have looked at effects of high doses of vitamin D on hypercalciuria, probably a more sensitive indicator of vitamin D excess."
"Total-body sun exposure easily provides the equivalent of 250 μg (10000 IU) vitamin D/d, suggesting that this is a physiologic limit."
"For vitamin D, a NOAEL could define the highest 25(OH)D concentration not suspected to cause hypercalciuria in healthy subjects. As discussed above, it could be difficult to prove that vitamin D is the cause of hypercalciuria because the condition is commonly caused by other things and it is a mild and nonclassicicl criterion for vitamin D intoxication. Nonetheless, because of the hypothesized predisposition to hypercalciuria of the Israeli lifeguards (25) and of the subjects in the study of Adams and Lee (16), 140 nmol 25(OH)D/L could be regarded as a very conservative limit for the NOAEL because the concentrations in those reports were higher than this. In the absence of sunshine, all available evidence indicates that this would require prolonged intake of ≈250 μg (10000 IU)/d to achieve. All of the reports of vitamin D toxicity showing the convincing evidence of hypercalcemia involve serum 25(OH)D concentrations well above 200 nmol/L (Table 5⇓), which requires a daily intake of ≥1000 μg (40000 IU), and which could thus be conservatively considered the LOAEL."
Este post foi editado por cyberots: 08:43:25 em 23/09/2012